Mechanism of palytoxin-induced Na+ influx into cultured bovine adrenal chromaffin cells: Possible involvement of Na+ H+ exchange system
M Yoshizumi, H Houchi, Y Ishimura, Y Masuda… - Neuroscience …, 1991 - Elsevier
To elucidate the mechanism of palytoxin (PTX)-induced Na+ influx, we examined the effect
of amiloride, an inhibitor of Na+ H+-antiporter, on PTX-induced Na+ influx into cultured
bovine adrenal chromaffin cells in relation to its effects on Ca 2+ influx and catecholamine
secretion. Amiloride dose-dependently inhibited PTX-induced 22 Na+ influx, whereas
tetrodotoxin (TTX) had no effect. Amiloride also inhibited PTX-induced Na+-dependent 45
Ca 2+ influx and catecholamine secretion. PTX alone did not significantly affect the …
of amiloride, an inhibitor of Na+ H+-antiporter, on PTX-induced Na+ influx into cultured
bovine adrenal chromaffin cells in relation to its effects on Ca 2+ influx and catecholamine
secretion. Amiloride dose-dependently inhibited PTX-induced 22 Na+ influx, whereas
tetrodotoxin (TTX) had no effect. Amiloride also inhibited PTX-induced Na+-dependent 45
Ca 2+ influx and catecholamine secretion. PTX alone did not significantly affect the …
